Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …

Acting through cell surface receptors, ADP activates platelets resulting in shape change,
aggregation, thromboxane A 2 production, and release of granule contents. ADP also causes a …

Background A cancer diagnosis can have a substantial impact on mental health and wellbeing.
Depression and anxiety may hinder cancer treatment and recovery, as well as quality of …

Depression is a polygenic trait that causes extensive periods of disability. Previous genetic
studies have identified common risk variants which have progressively increased in number …

Background Statin treatment and variants in the gene encoding HMG-CoA reductase are
associated with reductions in both the concentration of LDL cholesterol and the risk of coronary …

Winner of the IENE Project Award 2016. This authoritative volume brings together some of
the world’s leading researchers, academics, practitioners and transportation agency …

Personality is influenced by genetic and environmental factors 1 and associated with mental
health. However, the underlying genetic determinants are largely unknown. We identified …

People’s differences in cognitive functions are partly heritable and are associated with important
life outcomes. Previous genome-wide association (GWA) studies of cognitive functions …

Objectives UK Biobank is a landmark cohort of over 500,000 participants which will be used
to investigate genetic and non-genetic risk factors for a wide range of adverse health …