Irisin is secreted by muscle, increases with exercise, and mediates certain favorable effects
of physical activity. In particular, irisin has been shown to have beneficial effects in adipose …

Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close
proximity to hematopoietic cells in the bone marrow. Recurrent somatic mutations that lead to …

The purpose of this double-blind 14-week trial was to compare the efficacy of sustained-release
methylphenidate (MPH) to placebo (PBO) in treating adult attention deficit hyperactivity …

Cannabis dependence is a substantial public health problem. Behavioral treatments have
shown promise, but there are no effective medications for cannabis dependence. The purpose …

The purpose of this double-blind, three-arm, 12-week trial was to compare the efficacy of
sustained-release methylphenidate or sustained-release bupropion to placebo in treating adult …

Importance Adult attention-deficit/hyperactivity disorder (ADHD) is prevalent but often
unrecognized, in part because it tends to co-occur with other disorders such as substance use …

Parathyroid hormone (PTH) activates receptors on osteocytes to orchestrate bone formation
and resorption. Here we show that PTH inhibition of SOST (sclerostin), a WNT antagonist, …

Understanding the ionic diffusion mechanism in polymer electrolytes is critical to the
development of advanced lithium-ion batteries. We report here molecular dynamics-based …

Osteocytes, cells ensconced within mineralized bone matrix, are the primary skeletal
mechanosensors. Osteocytes sense mechanical cues by changes in fluid flow shear stress (FFSS) …

Osteoporosis is a major public health problem. Currently, there are no orally available
therapies that increase bone formation. Intermittent parathyroid hormone (PTH) stimulates bone …