… Correspondence and requests for reprints should be addressed to Daniel J. Jackson, MD,
University of Wisconsin Hospital, 600 Highland Avenue, K4/910, Madison, WI 53792. E-mail: […

Sponges are an ancient group of animals that diverged from other metazoans over 600 million
years ago. Here we present the draft genome sequence of Amphimedon queenslandica, …

SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) as its cellular receptor, as do
SARS-CoV and the coronavirus NL63. 1 Higher ACE2 expression increases in vitro …

BACKGROUND: The contribution of viral respiratory infections during infancy to the development
of subsequent wheezing and/or allergic diseases in early childhood is not established. …

The origin of many of the defining features of animal body plans, such as symmetry, nervous
system, and the mesoderm, remains shrouded in mystery because of major uncertainty …

Background Both genetic variation at the 17q21 locus and virus-induced respiratory wheezing
illnesses are associated with the development of asthma. Our aim was to determine the …

Background For children who have uncontrolled asthma despite the use of low-dose inhaled
corticosteroids (ICS), evidence to guide step-up therapy is lacking. Methods We randomly …

Members of rhinovirus C (RV-C) species are more likely to cause wheezing illnesses and
asthma exacerbations compared with other rhinoviruses. The cellular receptor for these …

… Correspondence and requests for reprints should be addressed to Daniel J. Jackson, MD,
Department of Pediatrics, Section of Allergy, Immunology and Rheumatology, University of …

Rationale: Human rhinoviruses (HRVs) consist of approximately 160 types that cause a wide
range of clinical outcomes, including asymptomatic infections, common colds, and severe …