Misregulation of Wnt signaling is at the root of many diseases, most notably colorectal
cancer, and although we understand the activation of the pathway, we have a very poor …

ER stress and apoptosis contribute to the loss of pancreatic β-cells under pro-diabetic
conditions of glucolipotoxicity. Although activation of canonical intrinsic apoptosis is known to …

Aims/hypothesis Beta cells control glucose homeostasis via regulated production and
secretion of insulin. This function arises from a highly specialised gene expression programme …

Restoring functional β cell mass is a potential therapy for those with diabetes. However, the
pathways regulating β cell mass are not fully understood. Previously, we demonstrated that …

In the progression of diabetes, pancreatic islet β-cells respond to increased metabolic demand
with functional compensation, followed by pathogenic decompensation of mitochondria-…

Histone 3 lysine 4 trimethylation (H3K4me3) is associated with promoters of actively
expressed genes, with genes important for cell identity frequently having exceptionally broad …

Background: Hedgehog interacting protein (Hhip) is essential for islet formation; however, its
role in the mature pancreas in response to high-fat diet (HFD)-mediated β-cell dysfunction …

Pyocyanin (1-hydroxy-N-methylphenazine, PCN) is a cytotoxic pigment and virulence factor
secreted by the human bacterial pathogen, Pseudomonas aeruginosa . Here, we report that …

Ring Laser Gyro (RLG) is used to sense angular information accurately and precisely. RLG
mainly depends on the pathlength, intensity and dithering. If path length changes there will …

The negative feedback inhibitor Axin2 is known to inhibit Wnt signaling by re-enabling the
destruction complex’s role in the degradation of cytoplasmic β-catenin. To better understand …