During brain neoplasia, malignant cells subjugate the immune system to provide an environment
that favors tumor growth. These mechanisms capitalize on tumor-promoting functions …

Cellular heterogeneity is a hallmark of advanced cancers and has been ascribed in part to a
population of self-renewing, therapeutically resistant cancer stem cells (CSCs). …

… Author links open overlay panel Daniel J Silver 1 , Jerry Silver 2 … -GAG-expressing human
breast carcinoma line M4A4 (DJ Silver, unpublished data). Importantly, we have demonstrated …

Glioblastoma remains one of the most lethal types of cancer, and is the most common brain
tumour in adults. In particular, tumour recurrence after surgical resection and radiation …

The transfer of intact mitochondria between heterogeneous cell types has been confirmed
in various settings, including cancer. However, the functional implications of mitochondria …

Trauma to the adult CNS initiates multiple processes including primary and secondary
axotomy, inflammation, and glial scar formation that have devastating effects on neuronal …

Shifting the balance away from tumor-mediated immune suppression toward tumor immune
rejection is the conceptual foundation for a variety of immunotherapy efforts currently being …

Peripherally conditioned sensory neurons have an increased capacity to regenerate their
central processes. However, even conditioned axons struggle in the presence of a hostile CNS …

Tumors contain hostile inflammatory signals generated by aberrant proliferation, necrosis,
and hypoxia. These signals are sensed and acted upon acutely by the Toll-like receptors (…

Sexual dimorphism at the level of MDSC subset prevalence, localization, and gene-expression
profile constitutes a therapeutic opportunity. Our results indicate that chemotherapy can …