Optical probes operating in the second near-infrared window (NIR-II, 1,000-1,700 nm),
where tissues are highly transparent, have expanded the applicability of fluorescence in the …

Tubulin-targeted chemotherapy has proven to be a successful and wide spectrum strategy
against solid and liquid malignancies. Therefore, new ways to modulate this essential protein …

Highlights • Ambient pH signaling involves both Pal and ESCRT components. • The receptor
module involves PalH, PalI and PalF. • The arrestin-like protein PalF is the toggle mediating …

Microtubules (MTs) are hollow cylinders made of tubulin, a GTPase responsible for essential
functions during cell growth and division, and thus, key target for anti-tumor drugs. In MTs, …

Microtubule-targeting agents (MTAs) like taxol and vinblastine are among the most successful
chemotherapeutic drugs against cancer. Here, we describe a fluorescence anisotropy-…

Paclitaxel (Taxol) is a taxane and a chemotherapeutic drug that stabilizes microtubules.
While the interaction of paclitaxel with microtubules is well described, the lack of high-resolution …

Microtubule-targeting agents (MTAs) are a class of clinically successful anti-cancer drugs.
The emergence of multidrug resistance to MTAs imposes the need for developing new MTAs …

Microtubule targeting agents (MTAs) have been exploited mainly as anti-cancer drugs
because of their impact on cellular division and angiogenesis. Additionally, microtubules (MTs) …

We describe the total synthesis of the macrodiolide C(13)/C(13′)‐bis(desmethyl)disorazole
Z through double inter‐/intramolecular Stille cross‐coupling of a monomeric vinyl stannane/…

Noscapine is a natural product first isolated from the opium poppy (Papaver somniferum L.)
with anticancer properties. In this work, we report the synthesis and cellular screening of a …