Mammals exhibit marked interindividual variations in their gut microbiota, but it remains
unclear if this is primarily driven by host genetics or by extrinsic factors like dietary intake. To …

The JAX Diversity Outbred population is a new mouse resource derived from partially
inbred Collaborative Cross strains and maintained by randomized outcrossing. As such, it …

The Diversity Outbred (DO) population is a heterogeneous stock derived from the same eight
founder strains as the Collaborative Cross (CC) inbred strains. Genetically heterogeneous …

Genetic variation modulates protein expression through both transcriptional and post-transcriptional
mechanisms. To characterize the consequences of natural genetic diversity on the …

R/qtl2 is an interactive software environment for mapping quantitative trait loci (QTL) in
experimental populations. The R/qtl2 software expands the scope of the widely-used R/qtl …

Background Maize (Zea mays) is a globally produced crop with broad genetic and phenotypic
variation. New tools that improve our understanding of the genetic basis of quantitative …

Genetic mapping studies in the mouse and other model organisms are used to search for
genes underlying complex phenotypes. Traditional genetic mapping studies that employ single…

The molecular bases of how host genetic variation impacts the gut microbiome remain
largely unknown. Here we used a genetically diverse mouse population and applied systems …

Background Inhalation of benzene at levels below the current exposure limit values leads to
hematotoxicity in occupationally exposed workers. Objective We sought to evaluate …

Pulmonary tuberculosis (TB) is caused by Mycobacterium tuberculosis in susceptible
humans. Here, we infected Diversity Outbred (DO) mice with ∼100 bacilli by aerosol to model …