Mammalian organogenesis is a remarkable process. Within a short timeframe, the cells of
the three germ layers transform into an embryo that includes most of the major internal and …

Chromosome conformation capture methods have identified subchromosomal structures of
higher-order chromatin interactions called topologically associated domains (TADs) that are …

The genome is organized in three-dimensional units called topologically associating domains
(TADs), through a process dependent on the cooperative action of cohesin and the DNA-…

Structural variations (SVs) contribute to the variability of our genome and are often
associated with disease. Their study in model systems was hampered until now by labor-intensive …

Expansions of amino acid repeats occur in >20 inherited human disorders, and many occur
in intrinsically disordered regions (IDRs) of transcription factors (TFs). Such diseases are …

Regulatory landscapes drive complex developmental gene expression, but it remains unclear
how their integrity is maintained when incorporating novel genes and functions during …

Complex regulatory landscapes control the pleiotropic transcriptional activities of
developmental genes. For most genes, the number, location, and dynamics of their associated …

The study of homeotic-transformation mutants in model organisms such as Drosophila
revolutionized the field of developmental biology, but how these mutants relate to human …

Balanced chromosomal rearrangements such as inversions and translocations can cause
congenital disease or cancer by inappropriately rewiring promoter–enhancer contacts 1 , 2 . …

Fibro-adipogenic progenitors (FAPs) are an interstitial cell population in adult skeletal
muscle that support muscle regeneration. During development, interstitial muscle connective …