Background Microarray technologies are established approaches for high throughput gene
expression, methylation and genotyping analysis. An accurate mapping of the array probes …

With the complete knowledge about the DNA sequence of human and other model organisms
like yeast, the foundation for a new, technology-driven era of biological research was laid …

The renin–angiotensin system plays a critical role in blood pressure control and body fluid
and electrolyte homeostasis. Besides angiotensin (Ang) II, other Ang peptides, such as Ang III […

The efficacy of implanted biomedical devices is often compromised by host recognition and
subsequent foreign body responses. Here, we demonstrate the role of the geometry of …

Objective To compare rates of a composite outcome of mortality or major morbidity in very-preterm/very
low birth weight infants between 8 members of the International Network for …

The transplantation of pancreatic islet cells could restore glycaemic control in patients with
type 1 diabetes. Microspheres for islet encapsulation have enabled long-term glycaemic …

Positively charged residues located near the cytoplasmic end of hydrophobic segments in
membrane proteins promote membrane insertion and formation of transmembrane α-helices. …

Tryptophan hydroxylase (TPH) is a rate limiting enzyme in the synthesis of serotonin (5-HT),
a monoamine which works as an autacoid in the periphery and as a neurotransmitter in the …

The angiotensin type 2 receptor (AT2R) and the receptor MAS are receptors of the protective
arm of the renin–angiotensin system. They mediate strikingly similar actions. Moreover, in …

The serine/threonine kinase TBK1 (TANK-binding kinase 1) and its homologue IKKε are
noncanonical members of the inhibitor of the nuclear factor κB (IκB) kinase family. These …