These findings characterize multiple deregulated mechanisms of genome stability that lead
to CIN in ovarian cancer and demonstrate the benefit of integrating analysis of said …

Digital PCR (dPCR) is an important tool for precise nucleic acid quantification in clinical setting,
but the limited multiplexing capability restricts its applications for quantitative gene panel …

Background: Advance Care Planning aims at improving alignment of care with patients’
preferences. This may affect costs of medical care. Aim: To determine the costs of an Advance …

Oncogene amplification is a major driver of cancer pathogenesis. Breakage fusion bridge (BFB)
cycles, like extrachromosomal DNA (ecDNA), can lead to high copy numbers of …

Interrogating regulatory epigenetic alterations during tumor progression at the resolution of
single cells has remained an understudied area of research. Here we developed the highly …

Utilizing T cells expressing chimeric antigen receptors (CARs) to identify and attack solid
tumors has proven challenging, in large part because of the lack of tumor-specific targets to …

… We thank Daniel Muliaditan for generating randomly placed genomic regions. NS was
funded by PCRF and Cancer Research UK. AM was funded by both PCRF and People …

Background: Adolescent and young adult advance care planning is beneficial in improving
communication between patients, surrogates, and clinicians. The influences on treatment …

Second generation (2G) chimeric antigen receptors (CARs) contain a CD28 or 41BB co-stimulatory
endodomain and elicit remarkable efficacy in hematological malignancies. Third …

… We thank Milou van Belzen for her support in adapting the ACP program to the Dutch context
and Daniel Muliaditan and Kim de Nooijer for their contribution to the medical file analyses. …