FusionCatcher is a software tool for finding somatic fusion genes in paired-end RNA-sequencing
data from human or other vertebrates. FusionCatcher achieves competitive detection …

Background Until recently, chromosomal translocations and fusion genes have been an
underappreciated class of mutations in solid tumors. Next-generation sequencing technologies …

Androgen receptor (AR) is expressed in all stages of prostate cancer progression, including
in castration-resistant tumors. Eliminating AR function continues to represent a focus of …

Recently, expression profiling of breast carcinomas has revealed gene signatures that
predict clinical outcome, and discerned prognostically relevant breast cancer subtypes. …

Human cord blood (CB)–derived CD133 + cells carry characteristics of primitive
hematopoietic cells and proffer an alternative for CD34 + cells in hematopoietic stem cell (HSC) …

Background & Aims: Although approximately 50% of Dukes’ C colorectal cancer patients are
surgically cured, it is currently not possible to distinguish these patients from those at high …

RNA-sequencing and tailored bioinformatic methodologies have paved the way for identification
of expressed fusion genes from the chaotic genomes of solid tumors. We have recently …

MicroRNAs (miRNAs) are small regulatory molecules that cause post-transcriptional gene
silencing. Although some miRNAs are known to have region-specific expression patterns in …

Simple Summary Prostate cancer lacks non-invasive specific biomarkers for aggressive
disease. Urinary extracellular vesicles (uEV) could provide such markers; however, due to …

The role of adrenal androgens as drivers for castration-resistant prostate cancer (CRPC)
growth in humans is generally accepted; however, the value of preclinical mouse models of …