Oxidative stress (OS) has been implicated in the pathophysiology of many neurological,
particularly neurodegenerative diseases. OS can cause cellular damage and subsequent cell …

Accumulating data indicate that oxidative stress (OS) plays a major role in the pathogenesis
of multiple sclerosis (MS). Reactive oxygen species (ROS), leading to OS, generated in …

Free radicals are highly reactive molecules generated predominantly during cellular respiration
and normal metabolism. Imbalance between cellular production of free radicals and the …

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) damages dopaminergic neurons in the
substantia nigra pars compacta (SNpc) as seen in Parkinson's disease. Here, we show that …

Amyotrophic lateral sclerosis (ALS) is a lethal disease, characterized by progressive death
of motor neurons with unknown etiology. Evidence from animal models indicates that …

Exosomes are emerging as effective therapeutic tools for various pathologies. These
extracellular vesicles can bypass biological barriers, including the blood-brain barrier, and can …

Importance Preclinical studies have shown that neurotrophic growth factors (NTFs) extend
the survival of motor neurons in amyotrophic lateral sclerosis (ALS) and that the combined …

The role of the proapototic Bax gene in ischemia-reperfusion (I/R) injury was studied in three
groups of mice: homozygotic knockout mice lacking the Bax gene (Bax −/− ), heterozygotic …

Individuals with spinal cord injury (SCI) usually suffer from permanent neurological deficits,
while spontaneous recovery and therapeutic efficacy are limited. Here, we demonstrate that …

Exosomes, nanovesicles that are secreted by different cell types, enable intercellular
communication at local or distant sites. Alhough they have been found to cross the blood brain …