This work evaluated the in vitro cytotoxic activity of laticifer proteins (LP) recovered from the
latex of the medicinal plant Calotropis procera. The LP displayed considerable cytotoxicity …

Chloroquine (CQ) and hydroxychloroquine (HCQ) are the most common drugs used to
relieve acute and chronic inflammatory diseases. In this article, we present a review about the …

… Daniel Pereira Bezerra surveyed the data and wrote the pharmacological part of the review.
Gardenia Carmen Gadelha Militão was responsible for the analysis of these data and wrote …

Cancer pain is a major public health problem worldwide due to the strong impact on the
quality of life of patients and side effects of the existing therapeutic options. Monoterpenes, as …

Piplartine {5,6-dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)pyridinone} is
an alkaloid/amide component of Piper species. The purpose of the present study was to …

Bioactive natural products play critical roles in modern drug development, especially
anticancer agents. It has been widely reported that various pharmacological activities of such …

The present work evaluated the cytotoxicity of piplartine {5,6-dihydro-1-[1-oxo-3-(3,4,5-
trimethoxyphenyl)-trans-2-propenyl]-2(1H)pyridinone} and piperine {1-[5-(1,3)-benzodioxol- 5-yl)-…

Combination of multifunctionalities into one compound is a rational strategy in medicinal
chemical design, and have often been used with metallodrug-based compounds. In the present …

The genus Piper belongs to the Piperaceae family, and includes species of commercial and
medicinal importance. Chemical studies on Piper species resulted in the isolation of several …

Agaricus blazei Murrill, a native mushroom of Brazil, has been widely consumed in different
parts of the world due to its anticancer potential. This effect is generally attributed to its …