Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze
protein crosslinking, plays an important role in the extracellular matrix biology of many tissues …

Linus Pauling established the conceptual framework for understanding and mimicking
enzymes more than six decades ago 1 . The notion that enzymes selectively stabilize the rate-…

Transglutaminase 2 (TG2) in the extracellular matrix is largely inactive but is transiently activated
upon certain types of inflammation and cell injury. The enzymatic activity of extracellular …

Biomaterials that mimic the extracellular matrix in both modularity and crosslinking chemistry
have the potential to recapitulate the instructive signals that ultimately control cell fate. …

Members of the casein kinase 1 (CK1) family of serine-threonine protein kinases are implicated
in the regulation of many cellular processes, including the cell cycle, circadian rhythms, …

Members of the potassium channel tetramerization domain (KCTD) family are soluble non-channel
proteins that commonly function as Cullin3 (Cul3)-dependent E3 ligases. Solution …

RIPK 2 mediates inflammatory signaling by the bacteria‐sensing receptors NOD 1 and NOD
2. Kinase inhibitors targeting RIPK 2 are a proposed strategy to ameliorate NOD ‐mediated …

The discovery of a pharmacological treatment for phenylketonuria (PKU) raised new questions
about function and dysfunction of phenylalanine hydroxylase (PAH), the enzyme deficient …

A series of 2-amino-2,3-dihydro-1H-indene-5-carboxamides were designed and synthesized
as new selective discoidin domain receptor 1 (DDR1) inhibitors. One of the representative …

Prolyl 4-hydroxylases are ascorbate-dependent oxygenases that play key roles in a variety
of eukaryotic biological processes including oxygen sensing, siRNA regulation, and collagen …