This article describes ferroptosis as a previously unappreciated mechanism of action for
radiotherapy. Further, it shows that ferroptosis is a novel point of synergy between …

… Analyses were performed using R (version 3.1.1; R Foundation for Statistical Computing,
Vienna, Austria). … Collection and assembly of data: Daniel R. Wahl, Matthew H. Stenmark …

The transfer of intact mitochondria between heterogeneous cell types has been confirmed
in various settings, including cancer. However, the functional implications of mitochondria …

Background Accurate prediction of tumour response to neoadjuvant chemoradiotherapy
enables personalised perioperative therapy for locally advanced rectal cancer. We aimed to …

Intratumoral genomic heterogeneity in glioblastoma (GBM) is a barrier to overcoming therapy
resistance. Treatments that are effective independent of genotype are urgently needed. By …

Cells generate adenosine triphosphate (ATP) by glycolysis and by oxidative phosphorylation
(OXPHOS). Despite the importance of having sufficient ATP available for the energy-…

This study demonstrates that ATM inhibition induces a T1IFN-mediated innate immune
response in pancreatic cancer that is further enhanced by radiation and leads to increased …

H3K27M diffuse intrinsic pontine gliomas (DIPGs) are fatal and lack treatments. They mainly
harbor H3.3K27M mutations resulting in H3K27me3 reduction. Integrated analysis in H3.…

For several decades, it has been known that T‐cell activation in vitro leads to increased
glycolytic metabolism that fuels proliferation and effector function. Recently, this simple model …

Effective therapies are lacking for patients with advanced colorectal cancer (CRC). The CRC
tumor microenvironment has elevated metabolic waste products due to altered metabolism …