Fast and selective isolation of single cells with unique spatial and morphological traits
remains a technical challenge. Here, we address this by establishing high-speed image-enabled …

The transcriptome contains rich information on molecular, cellular and organismal phenotypes.
However, experimental and statistical limitations constrain sensitivity and throughput of …

Cancer stem cells or cancer initiating cells are believed to contribute to cancer recurrence
after therapy. MicroRNAs (miRNAs) are short RNA molecules with fundamental roles in gene …

Exacerbated pro‐inflammatory immune response contributes to COVID‐19 pathology.
However, despite the mounting evidence about SARS‐CoV‐2 infecting the human gut, little is …

Here, we report the design, construction, and characterization of a tRNA neochromosome, a
designer chromosome that functions as an additional, de novo counterpart to the native …

During microRNA (miRNA)-guided gene silencing, Argonaute (Ago) proteins interact with a
member of the TNRC6/GW protein family. Here we used a short GW protein-derived peptide …

Severe forms of dilated cardiomyopathy (DCM) are associated with point mutations in the
alternative splicing regulator RBM20 that are frequently located in the arginine/serine-rich …

Small RNAs are important regulators of gene expression in many different organisms.
Nuclear and cytoplasmic biogenesis enzymes generate functional small RNAs from double-…

Assigning functions to genes and learning how to control their expression are part of the
foundation of cell biology and therapeutic development. An efficient and unbiased method to …

MicroRNAs (miRNAs) guide Argonaute (Ago) proteins to distinct target mRNAs leading to
translational repression and mRNA decay. Ago proteins interact with a member of the GW …