A close interaction between the virus SARS-CoV-2 and the immune system of an individual
results in a diverse clinical manifestation of the COVID-19 disease. While adaptive immune …

TRAIL (tumor-necrosis factor related apoptosis-inducing ligand, CD253) and its death
receptors TRAIL-R1 and TRAIL-R2 selectively trigger the apoptotic cell death in tumor cells. For …

Simple Summary MiR-155 appears to be a significant regulator of immune responses against
tumors. The aim of this review is to provide an overview of miR-155 function in distinct …

Mast cells, activated by Ag via FcεRI, release an array of proinflammatory mediators that
contribute to allergic disorders, such as asthma and anaphylaxis. The KIT ligand, stem cell factor …

IL-33 is elevated in afflicted tissues of patients with mast cell (MC)–dependent chronic allergic
diseases. Based on its acute effects on mouse MCs, IL-33 is thought to play a role in the …

Upregulated Wnt/β-catenin signaling is associated with increased cancer cell resistance and
cancer cell-elicited immunosuppression. In non-neoplastic immune cells, upregulated Wnt/β…

The exposure of phosphatidylserine (PS) on the cell surface is a general marker of apoptotic
cells. Non-apoptotic PS externalization is induced by several activation stimuli, including …

The immune checkpoint inhibitors have revolutionized cancer immunotherapy. These
inhibitors are game changers in many cancers and for many patients, sometimes show …

Increased mast cell burden is observed in the inflamed tissues and affected organs and
tissues of patients with mast cell proliferative disorders. However, normal mast cells participate …

Persistent dysregulation of IL-6 production and signaling have been implicated in the pathology
of various cancers. In systemic mastocytosis, increased serum levels of IL-6 associate …