The GWAS Catalog delivers a high-quality curated collection of all published genome-wide
association studies enabling investigations to identify causal variants, understand disease …

Open Targets Genetics ( https://genetics.opentargets.org ) is an open-access integrative
resource that aggregates human GWAS and functional genomics data including gene …

The Open Targets Platform ( https://platform.opentargets.org/ ) is an open source resource to
systematically assist drug target identification and prioritisation using publicly available data…

The Open Targets Platform ( https://www.targetvalidation.org/ ) provides users with a queryable
knowledgebase and user interface to aid systematic target identification and prioritisation …

Osteoarthritis is a common complex disease imposing a large public-health burden. Here,
we performed a genome-wide association study for osteoarthritis, using data across 16.5 …

We have identified a variant in ADCY3 (encoding adenylate cyclase 3) associated with markedly
increased risk of obesity and type 2 diabetes in the Greenlandic population. The variant …

Motivation Very low-depth sequencing has been proposed as a cost-effective approach to
capture low-frequency and rare variation in complex trait association studies. However, a full …

Osteoarthritis is the most common musculoskeletal disease and the leading cause of
disability globally. Here, we performed a genome-wide association study for osteoarthritis (77,052 …

Interacting proteins tend to have similar functions, influencing the same organismal traits.
Interaction networks can be used to expand the list of candidate trait-associated genes from …

LC8 dynein light chain (DYNLL) is a eukaryotic hub protein that is thought to function as a
dimerization engine. Its interacting partners are involved in a wide range of cellular functions. …