As cells enter mitosis, centrosomes dramatically increase in size and ability to nucleate
microtubules. This process, termed centrosome maturation, is driven by the accumulation and …

Chromosomes move toward mitotic spindle poles by a Pacman-flux mechanism linked to
microtubule depolymerization: chromosomes actively depolymerize attached microtubule plus …

Regulation of microtubule dynamics at the cell cortex is important for cell motility,
morphogenesis and division. Here we show that the Drosophila katanin Dm-Kat60 functions to …

Regulation of microtubule polymerization and depolymerization is required for proper cell
development. Here, we report that two proteins of the Drosophila melanogaster kinesin-13 …

Centriole duplication is a tightly regulated process that must occur only once per cell cycle;
otherwise, supernumerary centrioles can induce aneuploidy and tumorigenesis. Plk4 (Polo-…

Polo-like kinase 4 (Plk4) is a conserved master regulator of centriole assembly [1]. Previously,
we found that Drosophila Plk4 protein levels are actively suppressed during interphase [2]…

Centrioles are key microtubule polarity determinants. Centriole duplication is tightly
controlled to prevent cells from developing multipolar spindles, a situation that promotes …

Condensin complexes play vital roles in chromosome condensation during mitosis and meiosis.
Condensin II uniquely localizes to chromatin throughout the cell cycle and, in addition to …

Polo-like kinase 4 (Plk4) is a master regulator of centriole duplication, and its hyperactivity
induces centriole amplification. Homodimeric Plk4 has been shown to be ubiquitinated as a …

The poleward flux of tubulin subunits through spindle microtubules is a striking and conserved
phenomenon whose function and molecular components remain poorly understood. To …