User profiles for Daniela Verthelyi
 | Daniela VerthelyiFDA Verified email at fda.hhs.gov Cited by 9536 |
Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs
Oligodeoxynucleotides (ODN) that contain unmethylated CpG dinucleotides trigger a strong
innate immune response in vertebrates. CpG ODN show promise as vaccine adjuvants, anti-…
innate immune response in vertebrates. CpG ODN show promise as vaccine adjuvants, anti-…
Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality
…, G Winter, YX Fan, S Kirshner, D Verthelyi… - Journal of …, 2009 - jpharmsci.org
Therapeutic protein products provide unique and effective treatments for numerous human
diseases and medical conditions. In many cases, these treatments are used chronically to …
diseases and medical conditions. In many cases, these treatments are used chronically to …
Sex hormones as immunomodulators in health and disease
D Verthelyi - International immunopharmacology, 2001 - Elsevier
In addition to their effects on sexual differentiation and reproduction, sex hormones influence
the immune system. This results in a gender dimorphism in the immune function with …
the immune system. This results in a gender dimorphism in the immune function with …
Use of CpG oligodeoxynucleotides as immune adjuvants
…, D Currie, I Gursel, D Verthelyi - Immunological …, 2004 - Wiley Online Library
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis
…, J Pedras-Vasconcelos, D Verthelyi… - The Journal of …, 2007 - journals.aai.org
Multiple sclerosis (MS) is a CNS autoimmune disease believed to be triggered by T cells
secreting Th1-specific proinflammatory cytokines, such as GM-CSF. In the animal model of MS, …
secreting Th1-specific proinflammatory cytokines, such as GM-CSF. In the animal model of MS, …
Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide
Synthetic oligodeoxynucleotides (ODN) expressing “CpG motifs” show promise as immune
adjuvants, antiallergens, anticancer, and immunoprotective agents. Two structurally distinct …
adjuvants, antiallergens, anticancer, and immunoprotective agents. Two structurally distinct …
CpG oligodeoxynucleotides as vaccine adjuvants in primates
D Verthelyi, RT Kenney, RA Seder, AA Gam… - The journal of …, 2002 - journals.aai.org
Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune
adjuvants in mice, boosting the humoral and cellular response to coadministered Ags. CpG …
adjuvants in mice, boosting the humoral and cellular response to coadministered Ags. CpG …
[HTML][HTML] Lessons learned: new insights on the role of cytokines in COVID-19
…, JH Park, PL Schwartzberg, D Verthelyi… - Nature …, 2021 - nature.com
In the midst of resurging COVID-19 cases, the second NIH/FDA virtual COVID-19 and Cytokines
symposium was held on 1 December 2020, focusing on longitudinal studies of COVID-…
symposium was held on 1 December 2020, focusing on longitudinal studies of COVID-…
Neutralizing antibodies to therapeutic enzymes: considerations for testing, prevention and treatment
…, J Lozier, G Johnson, S Kirshner, D Verthelyi… - Nature …, 2008 - nature.com
Lysosomal storage diseases are characterized by deficiencies in lysosomal enzymes,
allowing accumulation of target substrate in cells and eventually causing cell death. Enzyme …
allowing accumulation of target substrate in cells and eventually causing cell death. Enzyme …
[HTML][HTML] Zika (PRVABC59) infection is associated with T cell infiltration and neurodegeneration in CNS of immunocompetent neonatal C57Bl/6 mice
M Manangeeswaran, DDC Ireland, D Verthelyi - PLoS pathogens, 2016 - journals.plos.org
The recent spread of Zika virus (ZIKV) and its association with increased rates of Guillain Barre
and other neurological disorders as well as congenital defects that include microcephaly …
and other neurological disorders as well as congenital defects that include microcephaly …