User profiles for Danielle A. Debruin

Danielle A Debruin

Victoria University
Verified email at vu.edu.au
Cited by 163

[HTML][HTML] Diversity in clinical and biomedical research: a promise yet to be fulfilled

…, NE Barcelo, MJ White, DM de Bruin… - PLoS …, 2015 - journals.plos.org
Esteban Gonzalez Burchard and colleagues explore how making medical research more
diverse would aid not only social justice but scientific quality and clinical effectiveness, too.

Lipid metabolism in sarcopenia

A Al Saedi, DA Debruin, A Hayes, M Hamrick - Bone, 2022 - Elsevier
Sarcopenia is an age-related disease associated with loss of muscle mass and strength. This
geriatric syndrome predisposes elderly individuals to a disability, falls, fractures, and death…

[HTML][HTML] The failed clinical story of myostatin inhibitors against Duchenne muscular dystrophy: exploring the biology behind the battle

E Rybalka, CA Timpani, DA Debruin, RM Bagaric… - Cells, 2020 - mdpi.com
Myostatin inhibition therapy has held much promise for the treatment of muscle wasting
disorders. This is particularly true for the fatal myopathy, Duchenne Muscular Dystrophy (DMD). …

The importance of mitochondrial quality control for maintaining skeletal muscle function across health span

J Sligar, DA DeBruin, NJ Saner… - American Journal of …, 2022 - journals.physiology.org
As the principal energy-producing organelles of the cell, mitochondria support numerous
biological processes related to metabolism, growth, and regeneration in skeletal muscle. …

[HTML][HTML] Dimethyl fumarate modulates the dystrophic disease program following short-term treatment

CA Timpani, S Kourakis, DA Debruin, DG Campelj… - JCI insight, 2023 - ncbi.nlm.nih.gov
New medicines are urgently required to treat the fatal neuromuscular disease Duchenne
muscular dystrophy (DMD). Dimethyl fumarate (DMF) is a potent immunomodulatory small …

[HTML][HTML] Assessment of the tocolytic nifedipine in preclinical primary models of preterm birth

…, NK Binder, N de Alwis, S Beard, DA Debruin… - Scientific reports, 2023 - nature.com
Spontaneous preterm birth is the leading cause of perinatal morbidity and mortality.
Tocolytics are drugs used in cases of imminent preterm birth to inhibit uterine contractions. …

[HTML][HTML] The effect of yearly-dose vitamin D supplementation on muscle function in mice

A Hayes, E Rybalka, DA Debruin, ED Hanson, D Scott… - Nutrients, 2019 - mdpi.com
Supplementation with vitamin D helps to alleviate weakness and fatigue seen with deficiency.
However, large bolus doses appear to worsen the risk of falls. Whether this occurs as a …

Exercise may ameliorate the detrimental side effects of high vitamin D supplementation on muscle function in mice

DA Debruin, CA Timpani, H Lalunio… - Journal of Bone and …, 2020 - Wiley Online Library
Vitamin D is commonly prescribed to normalize deficiencies and to treat osteoporosis. However,
the effect vitamin D supplements have on skeletal muscle health is equivocal. Although …

[HTML][HTML] Exploring new balance and gait factors that are associated with osteosarcopenia in patients with a previous fall and/or fracture history

DA Debruin, K Miksa, S Vogrin, G Duque… - Archives of gerontology …, 2024 - Elsevier
Osteosarcopenic individuals have poor muscle function and increased bone fragility, which
results in a severe detriment to health outcomes. Hence, there is a necessity to discover …

[HTML][HTML] The Effect of Vitamin D Supplementation on Skeletal Muscle in the mdx Mouse Model of Duchenne Muscular Dystrophy

DA Debruin, N Andreacchio, ED Hanson, CA Timpani… - Sports, 2019 - mdpi.com
Vitamin D (VitD) has shown to be beneficial in reversing muscle weakness and atrophy
associated with VitD deficiency. Duchenne muscular dystrophy is characterized by worsening …