The maintenance of the excitability of neurons and circuits is a fundamental process for
healthy brain functions. One of the main homeostatic mechanisms responsible for such …

Background Preprint usage is growing rapidly in the life sciences; however, questions
remain on the relative quality of preprints when compared to published articles. An objective …

Background Cellular differentiation is marked by temporally and spatially coordinated gene
expression regulated at multiple levels. DNA methylation represents a universal mechanism …

The corpus callosum (CC) is the largest white matter structure and the primary pathway for
interhemispheric brain communication. Investigating callosal connectivity is crucial to …

Mechanisms of homeostatic plasticity promote compensatory changes of cellular excitability
in response to chronic changes in the network activity. This type of plasticity is essential for …

Prolonged increases in excitation can trigger cell‐wide homeostatic responses in neurons,
altering membrane channels, promoting morphological changes, and ultimately reducing …

Importance Preprints have been increasingly used in biomedical science, and a key feature
of many platforms is public commenting. The content of these comments, however, has not …

Perinatal asphyxia remains a significant cause of neonatal mortality and is associated with
long-term neurodegenerative disorders. In the present study, we evaluated cellular and …

Background The Isotropic Fractionator (IF) is a method to determine the cellular composition
of nervous tissue. It has been mostly applied to assess variation across species, where …

Introduction Preprints have been increasingly used in biomedical sciences, providing the
opportunity for research to be publicly assessed before journal publication. With the increase in …