The magnitude and quality of the germinal center (GC) response decline with age, resulting
in poor vaccine-induced immunity in older individuals. A functional GC requires the co-…

Antibodies produced by antibody-secreting plasma cells (ASCs) underlie multiple forms of
long-lasting immunity. Here we examined the mechanisms regulating ASC turnover and …

Germinal centers (GCs), transient structures within B cell follicles and central to affinity
maturation, require the coordinated behavior of T and B cells. IL-21, a pleiotropic T cell-derived …

Vaccines work largely by generating long-lived plasma cells (LLPCs), but knowledge of how
such cells are recruited is sparse. Although it is clear that LLPCs preferentially originate in …

Naturally acquired humoral immunity to the malarial parasite Plasmodium falciparum can
protect against disease, although the precise mechanisms remain unclear. Although antibody …

The success of most vaccines relies on the generation of antibodies to provide protection
against subsequent infection; this in turn depends on a robust germinal centre (GC) response …

Influenza infection imparts an age-related increase in mortality and morbidity. The most
effective countermeasure is vaccination; however, vaccines offer modest protection in older …

The failure to generate enduring humoral immunity after vaccination is a hallmark of advancing
age. This can be attributed to a reduction in the germinal center (GC) response, which …

The generation of protective humoral immunity after vaccination relies on the productive
interaction between antigen-specific B cells and T follicular helper (Tfh) cells. Despite the central …

Background T follicular helper (Tfh) cells are key players in the production of antibody-producing
B cells via the germinal center reaction. Therapeutic strategies targeting Tfh cells are …