[PDF][PDF] Therapeutic deep brain stimulation in Parkinsonian rats directly influences motor cortex

Q Li, Y Ke, DCW Chan, ZM Qian, KKL Yung, H Ko… - Neuron, 2012 - cell.com
Much recent discussion about the origin of Parkinsonian symptoms has centered around the
idea that they arise with the increase of beta frequency waves in the EEG. This activity may …

Lipid‐bilayer‐supported 3D printing of human cerebral cortex cells reveals developmental interactions

L Zhou, AC Wolfes, Y Li, DCW Chan, H Ko… - Advanced …, 2020 - Wiley Online Library
Current understanding of human brain development is rudimentary due to suboptimal in
vitro and animal models. In particular, how initial cell positions impact subsequent human …

[HTML][HTML] Refinement of learned skilled movement representation in motor cortex deep output layer

Q Li, H Ko, ZM Qian, LYC Yan, DCW Chan… - Nature …, 2017 - nature.com
The mechanisms underlying the emergence of learned motor skill representation in primary
motor cortex (M1) are not well understood. Specifically, how motor representation in the …

[HTML][HTML] Antibody stabilization for thermally accelerated deep immunostaining

…, RAA Campbell, JCN Yau, CCY Chan, DCW Chan… - Nature …, 2022 - nature.com
Antibodies have diverse applications due to their high reaction specificities but are sensitive
to denaturation when a higher working temperature is required. We have developed a …

[HTML][HTML] An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish

SKH Sy, DCW Chan, RCH Chan, J Lyu, Z Li… - Nature …, 2023 - nature.com
Studying chemosensory processing desires precise chemical cue presentation, behavioral
response monitoring, and large-scale neuronal activity recording. Here we present Fish-on-…

[HTML][HTML] Prediction of forelimb reach results from motor cortex activities based on calcium imaging and deep learning

C Li, DCW Chan, X Yang, Y Ke… - Frontiers in cellular …, 2019 - frontiersin.org
Brain-wide activities revealed by neuroimaging and recording techniques have been used
to predict motor and cognitive functions in both human and animal models. However, …

Structure and biology of the intervertebral disk in health and disease

WCW Chan, KL Sze, D Samartzis… - Orthopedic …, 2011 - orthopedic.theclinics.com
Low back pain is a leading debilitating condition that affects every population worldwide, 1
and can lead to diminished physical function, loss of wages, decreased quality of life, and …

Coming together is a beginning: the making of an intervertebral disc

WCW Chan, TYK Au, V Tam… - … Research Part C …, 2014 - Wiley Online Library
The intervertebral disc (IVD) is a complex fibrocartilaginous structure located between the
vertebral bodies that allows for movement and acts as a shock absorber in our spine for daily …

Development of a standardized histopathology scoring system using machine learning algorithms for intervertebral disc degeneration in the mouse model—An ORS …

…, GJ Kerr, S Mohanty, V Tam, WCW Chan… - JOR …, 2021 - Wiley Online Library
Mice have been increasingly used as preclinical model to elucidate mechanisms and test
therapeutics for treating intervertebral disc degeneration (IDD). Several intervertebral disc (IVD…

Histological and reference system for the analysis of mouse intervertebral disc

V Tam, WCW Chan, VYL Leung… - Journal of …, 2018 - Wiley Online Library
A new scoring system based on histo‐morphology of mouse intervertebral disc (IVD) was
established to assess changes in different mouse models of IVD degeneration and repair. IVDs …