Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord

D Schnerwitzki, S Perry, A Ivanova… - Life science …, 2018 - life-science-alliance.org
Locomotion is coordinated by neuronal circuits of the spinal cord. Recently, dI6 neurons
were shown to participate in the control of locomotion. A subpopulation of dI6 neurons …

[HTML][HTML] Wt1 positive dB4 neurons in the hindbrain are crucial for respiration

D Schnerwitzki, C Hayn, B Perner… - Frontiers in Neuroscience, 2020 - frontiersin.org
Central pattern generator (CPG) networks coordinate the generation of rhythmic activity such
as locomotion and respiration. Their development is driven by various transcription factors, …

Adapting the pantograph limb: Differential robustness of fore-and hindlimb kinematics against genetically induced perturbation in the neural control networks and its …

D Schnerwitzki, C Englert, M Schmidt - Zoology, 2023 - Elsevier
The evolutionary transformation of limb morphology to the four-segmented pantograph of
therians is among the milestones of mammalian evolution. But, it is still unknown if changes of …

Dynamic association of flavin cofactors to regulate flavoprotein function

D Schnerwitzki, RM Vabulas - IUBMB life, 2022 - Wiley Online Library
Flavoproteins are key players in numerous redox pathways in cells. Flavin cofactors FMN and
FAD confer the required chemical reactivity to flavoenzymes. In most cases, the interaction …

[HTML][HTML] Alternative splicing of Wilms tumor suppressor 1 (Wt1) exon 4 results in protein isoforms with different functions

D Schnerwitzki, B Perner, B Hoppe, S Pietsch… - Developmental …, 2014 - Elsevier
The Wilms tumor suppressor gene Wt1 encodes a zinc finger transcription factor that is
essential for development of multiple organs including kidneys, gonads, spleen and heart. In …

Analysis of zebrafish Kidney Development with time-lapse imaging using a dissecting microscope equipped for optical sectioning

B Perner, D Schnerwitzki, M Graf, C Englert - JoVE (Journal of Visualized …, 2016 - jove.com
In order to understand organogenesis, the spatial and temporal alterations that occur during
development of tissues need to be recorded. The method described here allows time-lapse …

Wt1 positive neurons in the hindbrain are essential for respiration

D Schnerwitzki, C Hayn, B Perner, C Englert - bioRxiv, 2019 - biorxiv.org
Neuronal networks commonly referred to as central pattern generator (CPG) networks coordinate
the generation of rhythmic activity like locomotion and respiration. These networks are …

Loss of Wt1 in the murine spinal cord alters interneuron composition and locomotion

D Schnerwitzki, S Perry, A Ivanova, FV Caixeta… - bioRxiv, 2017 - biorxiv.org
Rhythmic and patterned locomotion is driven by spinal cord neurons that form neuronal circuits,
referred to as central pattern generators (CPGs). Recently, dI6 neurons were suggested …

Zebrafish Wtx is a negative regulator of Wnt signaling but is dispensable for embryonic development and organ homeostasis

A Große, B Perner, U Naumann… - Developmental …, 2019 - Wiley Online Library
… We are grateful to Eric Rivera-Milla for the initial expression analysis, to Manfred Schartl
for support in bioinformatics analysis, to Danny Schnerwitzki for help with statistics, to Randall …

[HTML][HTML] The Wilms Tumor Gene wt1a Contributes to Blood-Cerebrospinal Fluid Barrier Function in Zebrafish

VL Hopfenmüller, B Perner, H Reuter… - Frontiers in Cell and …, 2022 - frontiersin.org
The Wilms tumor suppressor gene Wt1 encodes a zinc finger transcription factor, which is
highly conserved among vertebrates. It is a key regulator of urogenital development and …