Large-scale transcriptional analysis of bovine embryo biopsies in relation to pregnancy success after transfer to recipients

…, F Rings, D Salilew, D Jennen… - Physiological …, 2006 - journals.physiology.org
The purpose of this work is to address the relationship between transcriptional profile of
embryos and the pregnancy success based on gene expression analysis of blastocyst biopsies …

Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification

DGJ Jennen, C Magkoufopoulou… - Toxicological …, 2010 - academic.oup.com
Direct comparison of the hepatoma cell lines HepG2 and HepaRG has previously been
performed by only evaluating a limited set of genes or proteins. In this study, we examined the …

Transcriptomic and metabolomic data integration

R Cavill, D Jennen, J Kleinjans… - Briefings in …, 2016 - academic.oup.com
Many studies now produce parallel data sets from different omics technologies; however,
the task of interpreting the acquired data in an integrated fashion is not trivial. This review …

[HTML][HTML] Applying'omics technologies in chemicals risk assessment: Report of an ECETOC workshop

…, J Hackermüller, B Hubesch, D Jennen… - Regulatory Toxicology …, 2017 - Elsevier
Prevailing knowledge gaps in linking specific molecular changes to apical outcomes and
methodological uncertainties in the generation, storage, processing, and interpretation of '…

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the …

J Jiang, JJ Briedé, DGJ Jennen, A Van Summeren… - Toxicology letters, 2015 - Elsevier
Acetaminophen (APAP) overdosage results in hepatotoxicity, but the underlying molecular
mechanisms are still not completely understood. In the current study, we focused on …

[HTML][HTML] An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin

A Ruiz-Aracama, A Peijnenburg, J Kleinjans, D Jennen… - BMC genomics, 2011 - Springer
Background In vitro cell systems together with omics methods represent promising
alternatives to conventional animal models for toxicity testing. Transcriptomic and proteomic …

Cord blood gene expression supports that prenatal exposure to perfluoroalkyl substances causes depressed immune functionality in early childhood

JLA Pennings, DGJ Jennen, UC Nygaard… - Journal of …, 2016 - Taylor & Francis
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a class of synthetic compounds
that have widespread use in consumer and industrial applications. PFAS are considered …

[HTML][HTML] ROS networks: designs, aging, Parkinson's disease and precision therapies

…, A Ignatenko, F Martorana, D Jennen… - NPJ systems biology …, 2020 - nature.com
How the network around ROS protects against oxidative stress and Parkinson’s disease (PD),
and how processes at the minutes timescale cause disease and aging after decades, …

Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma

…, M van Herwijnen, DHJ Theunissen, DGJ Jennen… - Toxicology, 2016 - Elsevier
Chronic exposure to aflatoxin B1 (AFB1) has, in certain regions in the world, been strongly
associated with hepatocellular carcinoma (HCC) development. AFB1 is a very potent …

Safer chemicals using less animals: kick-off of the European ONTOX project

…, E Fritsche, L Geris, R Gozalbes, T Hartung, D Jennen… - Toxicology, 2021 - Elsevier
The 3Rs concept, calling for replacement, reduction and refinement of animal experimentation,
is receiving increasing attention around the world, and has found its way to legislation, in …