User profiles for Daria Shlyueva
Daria ShlyuevaResearch associate, MSKCC Verified email at mskcc.org Cited by 2182 |
Transcriptional enhancers: from properties to genome-wide predictions
Cellular development, morphology and function are governed by precise patterns of gene
expression. These are established by the coordinated action of genomic regulatory elements …
expression. These are established by the coordinated action of genomic regulatory elements …
Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression
CRISPR interference (CRISPRi) represents a newly developed tool for targeted gene
repression. It has great application potential for studying gene function and mapping gene …
repression. It has great application potential for studying gene function and mapping gene …
PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia
…, E Lorenzini, S Kovalchuk, D Shlyueva… - Nature structural & …, 2019 - nature.com
Protein arginine methyltransferase 5 (PRMT5) has emerged as a promising cancer drug target,
and three PRMT5 inhibitors are currently in clinical trials for multiple malignancies. In this …
and three PRMT5 inhibitors are currently in clinical trials for multiple malignancies. In this …
Uncovering cis-regulatory sequence requirements for context-specific transcription factor binding
The regulation of gene expression is mediated at the transcriptional level by enhancer
regions that are bound by sequence-specific transcription factors (TFs). Recent studies have …
regions that are bound by sequence-specific transcription factors (TFs). Recent studies have …
[PDF][PDF] Hormone-responsive enhancer-activity maps reveal predictive motifs, indirect repression, and targeting of closed chromatin
Steroid hormones act as important developmental switches, and their nuclear receptors
regulate many genes. However, few hormone-dependent enhancers have been characterized, …
regulate many genes. However, few hormone-dependent enhancers have been characterized, …
[HTML][HTML] MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells
I Müller, AS Moroni, D Shlyueva, S Sahadevan… - Nature …, 2021 - nature.com
Deciphering the mechanisms that control the pluripotent ground state is key for understanding
embryonic development. Nonetheless, the epigenetic regulation of ground-state mouse …
embryonic development. Nonetheless, the epigenetic regulation of ground-state mouse …
[PDF][PDF] Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis
Acetylation of lysine 16 on histone H4 (H4K16ac) is catalyzed by histone acetyltransferase
KAT8 and can prevent chromatin compaction in vitro. Although extensively studied in …
KAT8 and can prevent chromatin compaction in vitro. Although extensively studied in …
[HTML][HTML] Probing the canonicity of the Wnt/Wingless signaling pathway
The hallmark of canonical Wnt signaling is the transcriptional induction of Wnt target genes
by the beta-catenin/TCF complex. Several studies have proposed alternative interaction …
by the beta-catenin/TCF complex. Several studies have proposed alternative interaction …
An alternative NURF complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions
Efficient treatment of acute myeloid leukemia (AML) patients remains a challenge despite
recent therapeutic advances. Here, using a CRISPRi screen targeting chromatin factors, we …
recent therapeutic advances. Here, using a CRISPRi screen targeting chromatin factors, we …
An integrated approach to study chromatin and transcriptional dynamics throughout the cell cycle without pharmacological inhibition
The cellular and nuclear states are constantly changing and closely linked to DNA replication
and cell division, defining cell cycle phases. Pharmacological inhibition is a widely used …
and cell division, defining cell cycle phases. Pharmacological inhibition is a widely used …