User profiles for Daria Shlyueva

Daria Shlyueva

Research associate, MSKCC
Verified email at mskcc.org
Cited by 2182

Transcriptional enhancers: from properties to genome-wide predictions

D Shlyueva, G Stampfel, A Stark - Nature Reviews Genetics, 2014 - nature.com
Cellular development, morphology and function are governed by precise patterns of gene
expression. These are established by the coordinated action of genomic regulatory elements …

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression

A Radzisheuskaya, D Shlyueva, I Müller… - Nucleic acids …, 2016 - academic.oup.com
CRISPR interference (CRISPRi) represents a newly developed tool for targeted gene
repression. It has great application potential for studying gene function and mapping gene …

PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia

…, E Lorenzini, S Kovalchuk, D Shlyueva… - Nature structural & …, 2019 - nature.com
Protein arginine methyltransferase 5 (PRMT5) has emerged as a promising cancer drug target,
and three PRMT5 inhibitors are currently in clinical trials for multiple malignancies. In this …

Uncovering cis-regulatory sequence requirements for context-specific transcription factor binding

…, HQ Dinh, EZ Kvon, D Shlyueva… - Genome …, 2012 - genome.cshlp.org
The regulation of gene expression is mediated at the transcriptional level by enhancer
regions that are bound by sequence-specific transcription factors (TFs). Recent studies have …

[PDF][PDF] Hormone-responsive enhancer-activity maps reveal predictive motifs, indirect repression, and targeting of closed chromatin

D Shlyueva, C Stelzer, D Gerlach, JO Yáñez-Cuna… - Molecular cell, 2014 - cell.com
Steroid hormones act as important developmental switches, and their nuclear receptors
regulate many genes. However, few hormone-dependent enhancers have been characterized, …

[HTML][HTML] MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells

I Müller, AS Moroni, D Shlyueva, S Sahadevan… - Nature …, 2021 - nature.com
Deciphering the mechanisms that control the pluripotent ground state is key for understanding
embryonic development. Nonetheless, the epigenetic regulation of ground-state mouse …

[PDF][PDF] Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis

A Radzisheuskaya, PV Shliaha, VV Grinev, D Shlyueva… - Molecular cell, 2021 - cell.com
Acetylation of lysine 16 on histone H4 (H4K16ac) is catalyzed by histone acetyltransferase
KAT8 and can prevent chromatin compaction in vitro. Although extensively studied in …

[HTML][HTML] Probing the canonicity of the Wnt/Wingless signaling pathway

A Franz, D Shlyueva, E Brunner, A Stark… - PLoS genetics, 2017 - journals.plos.org
The hallmark of canonical Wnt signaling is the transcriptional induction of Wnt target genes
by the beta-catenin/TCF complex. Several studies have proposed alternative interaction …

An alternative NURF complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions

…, PV Shliaha, AJ Cooper, Z Fan, D Shlyueva… - The EMBO …, 2023 - embopress.org
Efficient treatment of acute myeloid leukemia (AML) patients remains a challenge despite
recent therapeutic advances. Here, using a CRISPRi screen targeting chromatin factors, we …

An integrated approach to study chromatin and transcriptional dynamics throughout the cell cycle without pharmacological inhibition

D Shlyueva, S Teed-Singer, Y Zhan, R Koche, K Helin - bioRxiv, 2022 - biorxiv.org
The cellular and nuclear states are constantly changing and closely linked to DNA replication
and cell division, defining cell cycle phases. Pharmacological inhibition is a widely used …