Nonhuman primates represent the most relevant model organisms to understand the biology
of Homo sapiens. The recent divergence and associated overall sequence conservation …

Symbioses between bacteria and eukaryotes are ubiquitous, yet our understanding of the
interactions driving these associations is hampered by our inability to cultivate most host-…

Genetic diseases of blood cells are prime candidates for treatment through ex vivo gene
editing of CD34 + hematopoietic stem/progenitor cells (HSPCs), and a variety of technologies …

Annotators of the human genome are increasingly exploiting comparisons with genomes at
both the distal and proximal evolutionary edges of the vertebrate tree. Despite the sequence …

Background A feature common to all DNA sequencing technologies is the presence of base-call
errors in the sequenced reads. The implications of such errors are application specific, …

Background Small RNAs complex with proteins to mediate a variety of functions in animals
and plants. Some small RNAs, particularly miRNAs, circulate in mammalian blood and may …

Here we show that scavenger receptor class B type I is present in the small-intestine brush
border membrane where it facilitates the uptake of dietary cholesterol from either bile salt …

Signals from the surrounding niche drive proliferation and suppress differentiation of intestinal
stem cells (ISCs) at the bottom of intestinal crypts. Among sub-epithelial support cells, …

Small noncoding RNAs circulating in the blood may serve as signaling molecules because
of their ability to carry out a variety of cellular functions. We have previously described tRNA- …

Cytosine methylation in the genome of Drosophila melanogaster has been elusive and
controversial: Its location and function have not been established. We have used a novel and …