Mitochondria are dynamic organelles characterized by an ultrastructural organization which
is essential in maintaining their quality control and ensuring functional efficiency. The …

Membrane proteins are currently investigated after detergent extraction from native cellular
membranes and reconstitution into artificial liposomes or nanodiscs, thereby removing them …

Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen
when these channels are overexpressed in cell lines. Because prior work showed that the …

Piezo1 is a mechanosensitive channel involved in many cellular functions and responsible
for sensing shear stress and pressure forces in cells. Piezo1 has a unique trilobed topology …

Piezo1 forms a mechanically activated calcium-permeable nonselective cation channel that
is functionally important in many cell types. Structural data exist for C-terminal regions, but …

The discovery of PIEZO proteins has enabled better understanding of how cells respond to
mechanical force. 1-3 PIEZOs assemble to form ion channels that link force to cell behavior …

Mitofusins are large transmembrane GTPases of the dynamin-related protein family, and
are required for the tethering and fusion of mitochondrial outer membranes. Their full-length …

The activity of membrane proteins depends strongly on the surrounding lipid environment.
Here, we characterize the lipid stimulation of the plant plasma membrane H + -ATPase …

Anion exchanger 1 (AE1) is responsible for the exchange of bicarbonate and chloride across
the erythrocyte plasma membrane. Human AE1 consists of a cytoplasmic and a membrane …

Mycobacterium tuberculosis is protected from antibiotic therapy by a multi-layered hydrophobic
cell envelope. Major facilitator superfamily (MFS) transporter Rv1410 and the periplasmic …