Mutations in C9ORF72 are the most common cause of familial amyotrophic lateral sclerosis (ALS).
Here, through a combination of RNA-Seq and electrophysiological studies on …

Rodent-based studies have shown that the membrane properties of oligodendrocytes play
prominent roles in their physiology and shift markedly during their maturation from the …

Myelination is essential for central nervous system (CNS) formation, health, and function.
Emerging evidence of oligodendrocyte heterogeneity in health and disease and divergent CNS …

The corpus callosum (CC) is the major commissure that bridges the cerebral hemispheres.
Agenesis of the CC is associated with human ciliopathies, but the origin of this default is …

Regional patterning of the cerebral cortex is initiated by morphogens secreted by patterning
centers that establish graded expression of transcription factors within cortical progenitors. …

Early development of the hippocampus, which is essential for spatial memory and learning,
is controlled by secreted signaling molecules of the Wnt gene family and by Wnt/β-catenin …

Developing thalamocortical axons traverse the subpallium to reach the cortex located in the
pallium. We tested the hypothesis that descending corticofugal axons are important for …

10.7554/eLife.20337.001 Evolutionary differences in gene regulation between humans and
lower mammalian experimental systems are incompletely understood, a potential …

The corpus callosum (CC) is the largest commissure in the forebrain and mediates the transfer
of sensory, motor and cognitive information between the cerebral hemispheres. During …

The corpus callosum (CC) represents the major forebrain commissure connecting the 2
cerebral hemispheres. Midline crossing of callosal axons is controlled by several glial and …