User profiles for Darius Köster
 | Darius Vasco KösterAssociate Professor, University of Warwick, Centre for Mechanochemical Cell Biology, UK Verified email at warwick.ac.uk Cited by 1645 |
[HTML][HTML] Cells respond to mechanical stress by rapid disassembly of caveolae
The functions of caveolae, the characteristic plasma membrane invaginations, remain debated.
Their abundance in cells experiencing mechanical stress led us to investigate their role …
Their abundance in cells experiencing mechanical stress led us to investigate their role …
Actomyosin dynamics drive local membrane component organization in an in vitro active composite layer
The surface of a living cell provides a platform for receptor signaling, protein sorting, transport,
and endocytosis, whose regulation requires the local control of membrane organization. …
and endocytosis, whose regulation requires the local control of membrane organization. …
Cortical actin and the plasma membrane: inextricably intertwined
The plasma membrane serves as a barrier, separating the cell from its external environment.
Simultaneously it acts as a site for information transduction, entry of nutrients, receptor …
Simultaneously it acts as a site for information transduction, entry of nutrients, receptor …
EHD2 is a mechanotransducer connecting caveolae dynamics with gene transcription
Caveolae are small invaginated pits that function as dynamic mechanosensors to buffer
tension variations at the plasma membrane. Here we show that under mechanical stress, the …
tension variations at the plasma membrane. Here we show that under mechanical stress, the …
[PDF][PDF] Unexpected membrane dynamics unveiled by membrane nanotube extrusion
In cell mechanics, distinguishing the respective roles of the plasma membrane and of the
cytoskeleton is a challenge. The difference in the behavior of cellular and pure lipid …
cytoskeleton is a challenge. The difference in the behavior of cellular and pure lipid …
[HTML][HTML] Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells
Caveolin-3 is the major structural protein of caveolae in muscle. Mutations in the CAV3 gene
cause different types of myopathies with altered membrane integrity and repair, expression …
cause different types of myopathies with altered membrane integrity and repair, expression …
A composition-dependent molecular clutch between T cell signaling condensates and actin
10.7554/eLife.42695.001 During T cell activation, biomolecular condensates form at the
immunological synapse (IS) through multivalency-driven phase separation of LAT, Grb2, Sos1, …
immunological synapse (IS) through multivalency-driven phase separation of LAT, Grb2, Sos1, …
[HTML][HTML] The role of cell adhesion and cytoskeleton dynamics in the pathogenesis of the Ehlers-Danlos syndromes and hypermobility spectrum disorders
The Ehlers-Danlos syndromes (EDS) are a group of 13 disorders, clinically defined through
features of joint hypermobility, skin hyperextensibility, and tissue fragility. Most subtypes are …
features of joint hypermobility, skin hyperextensibility, and tissue fragility. Most subtypes are …
Calponin-homology domain mediated bending of membrane-associated actin filaments
…, A Suchenko, MK Balasubramanian, DV Köster - Elife, 2021 - elifesciences.org
Actin filaments are central to numerous biological processes in all domains of life. Driven by
the interplay with molecular motors, actin binding and actin modulating proteins, the actin …
the interplay with molecular motors, actin binding and actin modulating proteins, the actin …
Stratification relieves constraints from steric hindrance in the generation of compact actomyosin asters at the membrane cortex
Recent in vivo studies reveal that several membrane proteins are driven to form nanoclusters
by active contractile flows arising from localized dynamic patterning of F-actin and myosin …
by active contractile flows arising from localized dynamic patterning of F-actin and myosin …