User profiles for Darius V. Köster

Darius Vasco Köster

Associate Professor, University of Warwick, Centre for Mechanochemical Cell Biology, UK
Verified email at warwick.ac.uk
Cited by 1635

Actomyosin dynamics drive local membrane component organization in an in vitro active composite layer

DV Köster, K Husain, E Iljazi, A Bhat… - Proceedings of the …, 2016 - National Acad Sciences
The surface of a living cell provides a platform for receptor signaling, protein sorting, transport,
and endocytosis, whose regulation requires the local control of membrane organization. …

Cortical actin and the plasma membrane: inextricably intertwined

DV Köster, S Mayor - Current opinion in cell biology, 2016 - Elsevier
The plasma membrane serves as a barrier, separating the cell from its external environment.
Simultaneously it acts as a site for information transduction, entry of nutrients, receptor …

[HTML][HTML] Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells

M Dewulf, DV Köster, B Sinha… - Nature …, 2019 - nature.com
Caveolin-3 is the major structural protein of caveolae in muscle. Mutations in the CAV3 gene
cause different types of myopathies with altered membrane integrity and repair, expression …

A composition-dependent molecular clutch between T cell signaling condensates and actin

JA Ditlev, AR Vega, DV Köster, X Su, T Tani… - Elife, 2019 - elifesciences.org
10.7554/eLife.42695.001 During T cell activation, biomolecular condensates form at the
immunological synapse (IS) through multivalency-driven phase separation of LAT, Grb2, Sos1, …

[HTML][HTML] The role of cell adhesion and cytoskeleton dynamics in the pathogenesis of the Ehlers-Danlos syndromes and hypermobility spectrum disorders

S Malek, DV Köster - Frontiers in cell and developmental biology, 2021 - frontiersin.org
The Ehlers-Danlos syndromes (EDS) are a group of 13 disorders, clinically defined through
features of joint hypermobility, skin hyperextensibility, and tissue fragility. Most subtypes are …

Calponin-homology domain mediated bending of membrane-associated actin filaments

…, A Suchenko, MK Balasubramanian, DV Köster - Elife, 2021 - elifesciences.org
Actin filaments are central to numerous biological processes in all domains of life. Driven by
the interplay with molecular motors, actin binding and actin modulating proteins, the actin …

[PDF][PDF] Myosin II filament dynamics in actin networks revealed with interferometric scattering microscopy

…, A Fineberg, M Polin, S Mayor, P Kukura, DV Köster - Biophysical …, 2020 - cell.com
The plasma membrane and the underlying cytoskeletal cortex constitute active platforms for
a variety of cellular processes. Recent work has shown that the remodeling acto-myosin …

Phosphoregulation of tropomyosin is crucial for actin cable turnover and division site placement

S Palani, DV Köster, T Hatano, A Kamnev… - Journal of Cell …, 2019 - rupress.org
Tropomyosin is a coiled-coil actin binding protein key to the stability of actin filaments. In
muscle cells, tropomyosin is subject to calcium regulation, but its regulation in nonmuscle cells …

Pulling of tethers from the cell plasma membrane using optical tweezers

DV Köster - Caveolae: Methods and Protocols, 2020 - Springer
Here, we describe how to extract tethers or lipid membrane nanotubes from the plasma
membrane of cells using optical tweezers. This technique allows measuring the force required to …

A Python based automated tracking routine for myosin II filaments

LS Mosby, M Polin, DV Köster - Journal of Physics D: Applied …, 2020 - iopscience.iop.org
The study of motor protein dynamics within cytoskeletal networks is of high interest to physicists
and biologists to understand how the dynamics and properties of individual motors lead …