Intrinsically disordered proteins (IDPs) play important roles in disease pathologies; however,
their lack of defined stable 3D structures make traditional drug design strategies typically …

Over the past decade intrinsically disordered proteins (IDPs) have emerged as a biologically
important class of proteins, many of which are of therapeutic relevance. Here, we …

Surface plasmon resonance (SPR) biosensor methods are ideally suited for fragment-based
lead discovery. However, generally applicable experimental procedures and detailed …

Structural biology methods have determined 3D structures of many proteins describing their
mechanism of action and providing insights into their biological function. In recent years, the …

Until recently, the standard therapy for hepatitis C treatment has been interferon and ribavirin.
Such treatment has only 50% efficacy and is not well tolerated. The emergence of new …

Even though they account for 10% of the global disease burden and besides the new record
of funding in 2018, tropical diseases are still neglected by the majority of pharmaceutical …

FitzGerald, EA 2021. Fragment-based drug discovery. Novel methods and strategies for
identifying and evolving fragment leads. Digital Comprehensive Summaries of Uppsala …

Abdurakhmanov, E. 2015. Discovery and evaluation of direct acting antivirals against
hepatitis C virus. Digital Comprehensive Summaries of Uppsala Dissertations from the …