To understand how cells sense and adapt to mechanical stress, we applied tensional forces
to magnetic microbeads bound to cell-surface integrin receptors and measured changes in …

Integrins are ubiquitous transmembrane mechanoreceptors that elicit changes in intracellular
biochemistry in response to mechanical force application, but these alterations generally …

Aqueous humor outflow resistance is the primary determinant of intraocular pressure (IOP),
and increased outflow resistance is the basis for elevated IOP associated with glaucoma. …

Cultured trabecular meshwork (TM) cells are a valuable model system to study the cellular
mechanisms involved in the regulation of conventional outflow resistance and thus intraocular …

Aqueous humor flows out of the eye primarily through the conventional outflow pathway that
includes the trabecular meshwork and Schlemm's canal. However, a fraction of aqueous …

purpose. To understand how hydrodynamic and morphologic changes in the aqueous
humor outflow pathway contribute to decreased aqueous humor outflow facility after acute …

Purpose.: Pathology in the primary drainage pathway for aqueous humor in the eye is
responsible for ocular hypertension, the only treatable risk factor in patients with glaucoma. …

Increased flow resistance is responsible for the elevated intraocular pressure characteristic
of glaucoma, but the cause of this resistance increase is not known. We tested the hypothesis …

Ocular hypertension in glaucoma develops due to age-related cellular dysfunction in the
conventional outflow tract, resulting in increased resistance to aqueous humor outflow. Two cell …

Rho-kinase inhibitor Y-27632 (Y-27) affects actomyosin cytoskeletal networks and has been
shown to significantly increase outflow facility (C) in enucleated porcine and rabbit eyes, as …