Complex gene regulatory networks require transcription factors (TFs) to bind distinct DNA
sequences. To understand how novel TF specificity evolves, we combined phylogenetic, …

… Now Anderson, McKeown and Thornton have characterized … To reconstruct these ancestral
proteins, Anderson, McKeown … Anderson, McKeown and Thornton then reconstructed all the …

DM‐W is a dominant, female‐specific, regulator of sex determination in the African clawed
frog Xenopus laevis. This gene is derived from partial duplication of DMRT1, a male‐related …

Characterizing the adaptive landscapes that encompass the emergence of novel enzyme
functions can provide molecular insights into both enzymatic and evolutionary mechanisms. …

We present a detailed computational study of the assembly of protostellar discs and massive
stars in molecular clouds with supersonic turbulence. We follow the evolution of large-scale …

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a key member of the
phosphatidylinositol-3 kinase-like (PIKK) family of protein kinases with critical roles in DNA-double …

Enzymes can evolve new catalytic activity when environmental changes present them with
novel substrates. Despite this seemingly straightforward relationship, factors other than the …

Epistasis occurs when the combined effect of two or more mutations differs from the sum of
their individual effects, and reflects molecular interactions that affect the function and fitness of …

Integrative computational methods can facilitate the discovery of new protein functions and
enzymatic reactions by enabling the observation and investigation of complex sequence-…

SARS-CoV-2 is a unique event, having emerged suddenly as a highly infectious viral
pathogen for human populations. Previous phylogenetic analyses show its closest known …