The endogenous cannabinoid receptor agonist anandamide 1 is a powerful vasodilator of
isolated vascular preparations 2 , 3 , 4 , but its mechanism of action is unclear. Here we show …

Mammals detect temperature with specialized neurons in the peripheral nervous system.
Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class …

A distinct subset of sensory neurons are thought to directly sense changes in thermal
energy through their termini in the skin. Very little is known about the molecules that mediate …

Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate
in the skin. Three members of the transient receptor potential (TRP) family of channels are …

Transient receptor potential A1 (TRPA1) is expressed in a subset of nociceptive sensory
neurons where it acts as a sensor for environmental irritants, including acrolein, and some …

Oxides with the cubic fluorite structure, eg, ceria (CeO 2 ), are known to be good solid
electrolytes when they are doped with cations of lower valence than the host cations. The high …

Acetaminophen (paracetamol) is a popular domestic analgesic and antipyretic agent with a
weak anti-inflammatory action and a low incidence of adverse effects as compared with …

The electronic structure and thermodynamic properties of Ce O 2 and Ce 2 O 3 have been
studied from first principles by the all-electron projector-augmented-wave (PAW) method, as …

Fibromyalgia syndrome (FMS) is characterized by widespread pain and tenderness, and
patients typically experience fatigue and emotional distress. The etiology and pathophysiology …

TRPA1 is a unique sensor of noxious stimuli and, hence, a potential drug target for analgesics.
Here we show that the antinociceptive effects of spinal and systemic administration of …