Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on …

RA Sperling, PS Aisen, LA Beckett, DA Bennett… - Alzheimer's & …, 2011 - Elsevier
The pathophysiological process of Alzheimer’s disease (AD) is thought to begin many years
before the diagnosis of AD dementia. This long “preclinical” phase of AD would provide a …

Single-cell transcriptomic analysis of Alzheimer's disease

…, AJ Martorell, RM Ransohoff, BP Hafler, DA Bennett… - Nature, 2019 - nature.com
Alzheimer’s disease is a pervasive neurodegenerative disorder, the molecular complexity of
which remains poorly understood. Here, we analysed 80,660 single-nucleus transcriptomes …

[HTML][HTML] Participation in cognitively stimulating activities and risk of incident Alzheimer disease

…, JA Schneider, JL Bienias, DA Evans, DA Bennett - Jama, 2002 - jamanetwork.com
ContextFrequent participation in cognitively stimulating activities has been hypothesized to
reduce risk of Alzheimer disease (AD), but prospective data regarding an association are …

Alzheimer disease in the US population: prevalence estimates using the 2000 census

…, PA Scherr, JL Bienias, DA Bennett… - Archives of …, 2003 - jamanetwork.com
Context Current and future estimates of Alzheimer disease (AD) are essential for public
health planning. Objective To provide prevalence estimates of AD for the US population from …

[HTML][HTML] NIA-AA research framework: toward a biological definition of Alzheimer's disease

CR Jack Jr, DA Bennett, K Blennow, MC Carrillo… - Alzheimer's & …, 2018 - Elsevier
In 2011, the National Institute on Aging and Alzheimer's Association created separate diagnostic
recommendations for the preclinical, mild cognitive impairment, and dementia stages of …

Mixed brain pathologies account for most dementia cases in community-dwelling older persons

JA Schneider, Z Arvanitakis, W Bang, DA Bennett - Neurology, 2007 - AAN Enterprises
Objective: To examine the spectrum of neuropathology in persons from the Rush Memory
and Aging Project, a longitudinal community-based clinical-pathologic cohort study. Methods: …

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

…, D Blacker, S Mead, TH Mosley Jr, DA Bennett… - Nature …, 2013 - nature.com
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …

Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and …

…, TE Golde, VA Petyuk, PL De Jager, DA Bennett… - Nature medicine, 2020 - nature.com
Our understanding of Alzheimer’s disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …

Religious orders study and rush memory and aging project

DA Bennett, AS Buchman, PA Boyle… - Journal of …, 2018 - content.iospress.com
Background: The Religious Orders Study and Rush Memory and Aging Project are both
ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer’s disease (AD). …

Diagnosis and management of dementia

Z Arvanitakis, RC Shah, DA Bennett - Jama, 2019 - jamanetwork.com
Importance Worldwide, 47 million people live with dementia and, by 2050, the number is
expected to increase to 131 million. Observations Dementia is an acquired loss of cognition in …