Dynamic regulation of adhesion complexes is required for cell migration and has therefore
emerged as a key issue in the study of cell motility 1 . Recent progress has been made in …

The coordinated and dynamic regulation of adhesions is required for cell migration. We
demonstrated previously that limited proteolysis of talin1 by the calcium-dependent protease …

Cyclin G2, together with cyclin G1 and cyclin I, defines a novel cyclin family expressed in
terminally differentiated tissues including brain and muscle. Cyclin G2 expression is up-…

The dynamic turnover of integrin-mediated adhesions is important for cell migration. Paxillin
is an adaptor protein that localizes to focal adhesions and has been implicated in cell motility…

Direct visualization and characterization of Cxcr2 signaling as a mediator of systemic
neutrophil reaction to a local infection. Neutrophils are the first line of defense against tissue …

PSTPIP1 is a cytoskeletal adaptor and F-BAR protein that has been implicated in autoinflammatory
disease, most notably in the PAPA syndrome: pyogenic sterile arthritis, pyoderma …

T cell–APC contact initiates T cell activation and is maintained by the integrin LFA-1. Talin1,
an LFA-1 regulator, localizes to the immune synapse (IS) with unknown roles in T cell …

Neutrophil migration is essential for inflammatory responses to kill pathogens; however,
excessive neutrophilic inflammation also leads to tissue injury and adverse effects. To discover …

Cyclin G2 is an atypical cyclin that associates with active protein phosphatase 2A. Cyclin G2
gene expression correlates with cell cycle inhibition; it is significantly upregulated in …

Neutrophil recruitment to tissue damage is essential for host defense but can also impede
tissue repair. The cues that differentially regulate neutrophil responses to tissue damage and …