The extracellular matrix (ECM) plays a key role in synaptogenesis and the regulation of
synaptic functions in the central nervous system. Recent studies revealed that in addition to …

Background Paediatric sepsis remains a major public health problem with significant
morbidity and mortality especially in developing countries. Clinical symptoms associated with …

Understanding changes in the expression of genes involved in regulating various components
of the neural extracellular matrix (ECM) during aging can provide an insight into aging-…

In the advanced stages of Alzheimer's disease (AD), microglia are transformed to an activated
phenotype with thickened and retracted processes, migrate to the site of amyloid‐beta (Aβ…

Objective The incidence of gestational diabetes mellitus (GDM) and metabolic disorders
during pregnancy are increasing globally. This has resulted in increased use of therapeutic …

Our previous studies demonstrated that enzymatic removal of highly sulfated heparan sulfates
with heparinase 1 impaired axonal excitability and reduced expression of ankyrin G at the …

The condensed form of neural extracellular matrix (ECM), perineuronal nets (PNNs), is
predominantly associated with parvalbumin-expressing (PV+) interneurons in the cortex and …

The neural extracellular matrix (ECM) accumulates in the form of perineuronal nets (PNNs),
particularly around fast-spiking GABAergic interneurons in the cortex and hippocampus, but …

Neural extracellular matrix (ECM) is a complex molecular meshwork surrounding neurons
and glial cells in the extracellular space. Structural and functional state of ECM in the brain is …

Age-dependent accumulation of extracellular matrix (ECM) molecules is implicated in the
age-associated decline in synaptic and cognitive functions, which is the common phenotype of …