Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips
…, M Ingram, A Chalkiadaki, D Benson Chou… - Nature biomedical …, 2020 - nature.com
Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in
animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD …
animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD …
Robotic fluidic coupling and interrogation of multiple vascularized organ chips
…, A Chalkiadaki, A Cho, Y Choe, DB Chou… - Nature biomedical …, 2020 - nature.com
Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and
pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we …
pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we …
[HTML][HTML] A robotic platform for fluidically-linked human body-on-chips experimentation
…, A Chalkiadaki, A Cho, Y Choe, DB Chou… - Nature biomedical …, 2020 - ncbi.nlm.nih.gov
Here we describe of an ‘Interrogator’instrument that uses liquid-handling robotics, a custom
software package, and an integrated mobile microscope to enable automated culture, …
software package, and an integrated mobile microscope to enable automated culture, …
[HTML][HTML] Quantitative prediction of human drug pharmacokinetic responses using multiple vascularized organ chips coupled by fluid transfer
…, M Ingram, A Chalkiadaki, DB Chou… - Nature biomedical …, 2020 - ncbi.nlm.nih.gov
Pharmacokinetic and pharmacodynamic (PK/PD) analysis required to advance drug
compounds towards clinical testing is commonly carried out in animals, however, the results are …
compounds towards clinical testing is commonly carried out in animals, however, the results are …
Visual H2 sensor for monitoring biodegradation of magnesium implants in vivo
…, W Hoagland, D Benson, Z Dong, S Chen, DT Chou… - Acta biomaterialia, 2016 - Elsevier
A visual sensor for H 2 was used to transdermally monitor H 2 that originated from biodegrading
magnesium (Mg) alloys implanted subcutaneously in mice. The visual sensor consisted …
magnesium (Mg) alloys implanted subcutaneously in mice. The visual sensor consisted …
Visual hydrogen mapping sensor for noninvasive monitoring of bioresorbable magnesium implants in vivo
The biodegradation process of Mg alloys (LAZ611 and WKX41) has been monitored
transdermally by using a visual H 2 mapping sensor. The visual mapping sensor changes color …
transdermally by using a visual H 2 mapping sensor. The visual mapping sensor changes color …
[PDF][PDF] Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips
…, SSF Jeanty, M Ingram, A Chalkiadaki, DB Chou… - Kidney - academia.edu
Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in
animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD …
animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD …
[PDF][PDF] Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection
Using a model of lethal oral infection with Toxoplasma gondii, we examined the fate of both
induced and natural regulatory T (Treg) cells in the face of strong inflammatory responses …
induced and natural regulatory T (Treg) cells in the face of strong inflammatory responses …
Analytical and computational description of effect of grain size on yield stress of metals
HH Fu, DJ Benson, MA Meyers - Acta materialia, 2001 - Elsevier
Four principal factors contribute to grain-boundary strengthening: (a) the grain boundaries
act as barriers to plastic flow; (b) the grain boundaries act as dislocation sources; (c) elastic …
act as barriers to plastic flow; (b) the grain boundaries act as dislocation sources; (c) elastic …
On the effect of grain size on yield stress: extension into nanocrystalline domain
DJ Benson, HH Fu, MA Meyers - Materials Science and Engineering: A, 2001 - Elsevier
Four principal factors contribute to grain-boundary strengthening: (a) the grain boundaries
act as barriers to plastic flow; (b) the grain boundaries act as dislocation sources; (c) elastic …
act as barriers to plastic flow; (b) the grain boundaries act as dislocation sources; (c) elastic …