Mnemonic discrimination, the ability to distinguish similar events in memory, relies on
subregions in the human medial temporal lobes (MTLs). Tau pathology is frequently found within …

Importance There is an urgent need for inexpensive and minimally invasive blood biomarkers
for Alzheimer disease (AD) that could be used to detect early disease changes. Objective …

The hippocampus is proposed to be critical in distinguishing between similar experiences by
performing pattern separation computations that create orthogonalized representations for …

In Alzheimer’s disease, post-mortem studies have shown that the first cortical site where
neurofibrillary tangles appear is the transentorhinal region, a subregion within the medial …

Peripheral processes that mediate beneficial effects of exercise on the brain remain sparsely
explored. Here, we show that a muscle secretory factor, cathepsin B (CTSB) protein, is …

Human episodic memory critically depends on subregions of the medial temporal lobe,
which are part of functional brain systems such as the anterior-temporal and the posterior-medial …

10.7554/eLife.06426.001 The entorhinal cortex (EC) is the primary site of interactions between
the neocortex and hippocampus. Studies in rodents and nonhuman primates suggest that …

… David Berron is supported by the European Union's Horizon 2020 research and innovation
… David Berron has co-founded neotiv GmbH and owns shares. Kathryn V. Papp has served …

There is an increasing role for biological markers (biomarkers) in the understanding and
diagnosis of neurodegenerative disorders. The application of imaging biomarkers specifically …

The advent of high‐resolution magnetic resonance imaging (MRI) has enabled in vivo
research in a variety of populations and diseases on the structure and function of hippocampal …