The crystal structure of Escherichia coli GroEL shows a porous cylinder of 14 subunits made
of two nearly 7-fold rotationally symmetrical rings stacked back-to-back with dyad symmetry. …

GroEL is a bacterial chaperonin of 14 identical subunits required to help fold newly synthesized
proteins. The crystal structure of GroEL with ATPγS bound to each subunit shows that …

A 10-bit 80-MS/s analog-to-digital converter (ADC) with an area- and power-efficient architecture
is described. By sharing an amplifier between two successive pipeline stages, a 10-bit …

Studies of the proteome would benefit greatly from methods to directly sequence and digitally
quantify proteins and detect posttranslational modifications with single-molecule sensitivity…

Fibrillarin is a phylogenetically conserved protein essential for efficient processing of pre‐rRNA
through its association with a class of small nucleolar RNAs during ribosomal biogenesis…

SU9516 is a 3-substituted indolinone compound with demonstrated potent and selective
inhibition toward cyclin dependent kinases (cdks). Here, we describe the kinetic …

A 10 b 80 MHz pipelined ADC with an active area of 1.85 mm/sup 2/ is realized in a 0.18 /spl
mu/m dual gate oxidation CMOS process and achieves 72.8 dBc SFDR, 57.92 dB SNR, and …

Background Reverse transcriptase (RT) from HIV-1 is responsible for replicating the single-stranded
RNA genome to double-stranded DNA. The three-dimensional structure of RT …

The crystal structure of the hypothetical protein MJ1247 from Methanococccus jannaschii at
2 Å resolution, a detailed sequence analysis, and biochemical assays infer its molecular …

Metis are an aboriginal people with a long and important history in Canada-a people that has
had its _ aboriginal rights denied for too long. We will describe in this paper how the Metis …