Many common variants have been associated with hematological traits, but identification of
causal genes and pathways has proven challenging. We performed a genome-wide …

Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high-…

The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …

The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical
advances by enabling the responsible sharing of clinical and genomic data through both …

The International Human Epigenome Consortium (IHEC) coordinates the production of
reference epigenome maps through the characterization of the regulome, methylome, and …

The incidence of type 1 diabetes (T1D) has substantially increased over the past decade,
suggesting a role for non-genetic factors such as epigenetic mechanisms in disease …

Background With the decreasing cost of sequencing and the rapid developments in genomics
technologies and protocols, the need for validated bioinformatics software that enables …

Humans display remarkable interindividual variation in their immune response to identical
challenges. Yet, our understanding of the genetic and epigenetic factors contributing to such …

We present the Canadian Open Neuroscience Platform (CONP) portal to answer the research
community’s need for flexible data sharing resources and provide advanced tools for …

We present the Canadian Distributed Infrastructure for Genomics (CanDIG) platform, which
enables federated querying and analysis of human genomics and linked biomedical data. …