[HTML][HTML] The inflammation-associated protein TSG-6 cross-links hyaluronan via hyaluronan-induced TSG-6 oligomers
NS Baranova, E Nilebäck, FM Haller, DC Briggs… - Journal of Biological …, 2011 - ASBMB
Tumor necrosis factor-stimulated gene-6 (TSG-6) is a hyaluronan (HA)-binding protein that
plays important roles in inflammation and ovulation. TSG-6-mediated cross-linking of HA has …
plays important roles in inflammation and ovulation. TSG-6-mediated cross-linking of HA has …
The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia
Killer immunoglobulin–like receptors (KIRs) regulate cell activity of natural killer (NK) cells
and some T cells. The predominant ligand for inhibitory KIRs is HLA-C, which subdivides into …
and some T cells. The predominant ligand for inhibitory KIRs is HLA-C, which subdivides into …
[HTML][HTML] The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2
…, M Marcellini, V Rivieccio, DC Briggs… - Journal of Biological …, 2010 - ASBMB
The inflammation-associated long pentraxin PTX3 plays key roles in innate immunity,
female fertility, and vascular biology (eg it inhibits FGF2 (fibroblast growth factor 2)-mediated …
female fertility, and vascular biology (eg it inhibits FGF2 (fibroblast growth factor 2)-mediated …
Structural basis of laminin binding to the LARGE glycans on dystroglycan
Dystroglycan is a highly glycosylated extracellular matrix receptor with essential functions in
skeletal muscle and the nervous system. Reduced matrix binding by α-dystroglycan (α-DG) …
skeletal muscle and the nervous system. Reduced matrix binding by α-dystroglycan (α-DG) …
[HTML][HTML] Molecular mechanism of decision-making in glycosaminoglycan biosynthesis
Two major glycosaminoglycan types, heparan sulfate (HS) and chondroitin sulfate (CS), control
many aspects of development and physiology in a type-specific manner. HS and CS are …
many aspects of development and physiology in a type-specific manner. HS and CS are …
Structure of the food-poisoning Clostridium perfringens enterotoxin reveals similarity to the aerolysin-like pore-forming toxins
DC Briggs, CE Naylor, JG Smedley III… - Journal of molecular …, 2011 - Elsevier
Clostridium perfringens enterotoxin (CPE) is a major cause of food poisoning and antibiotic-associated
diarrhea. Upon its release from C. perfringens spores, CPE binds to its receptor, …
diarrhea. Upon its release from C. perfringens spores, CPE binds to its receptor, …
Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation
Protein glycosylation events that happen early in the secretory pathway are often dysregulated
during tumorigenesis. These events can be probed, in principle, by monosaccharides …
during tumorigenesis. These events can be probed, in principle, by monosaccharides …
[HTML][HTML] Incorporation of pentraxin 3 into hyaluronan matrices is tightly regulated and promotes matrix cross-linking
Mammalian oocytes are surrounded by a highly hydrated hyaluronan (HA)-rich extracellular
matrix with embedded cumulus cells, forming the cumulus cell·oocyte complex (COC) matrix…
matrix with embedded cumulus cells, forming the cumulus cell·oocyte complex (COC) matrix…
[HTML][HTML] Inter-α-inhibitor impairs TSG-6-induced hyaluronan cross-linking
NS Baranova, SJ Foulcer, DC Briggs… - Journal of Biological …, 2013 - ASBMB
Under inflammatory conditions and in the matrix of the cumulus-oocyte complex, the
polysaccharide hyaluronan (HA) becomes decorated covalently with heavy chains (HCs) of the …
polysaccharide hyaluronan (HA) becomes decorated covalently with heavy chains (HCs) of the …
[HTML][HTML] Metal ion-dependent heavy chain transfer activity of TSG-6 mediates assembly of the cumulus-oocyte matrix
DC Briggs, HL Birchenough, T Ali, MS Rugg… - Journal of Biological …, 2015 - ASBMB
The matrix polysaccharide hyaluronan (HA) has a critical role in the expansion of the cumulus
cell-oocyte complex (COC), a process that is necessary for ovulation and fertilization in …
cell-oocyte complex (COC), a process that is necessary for ovulation and fertilization in …