Mutations in the human α-tectorin gene cause autosomal dominant non-syndromic hearing impairment
…, LV Laer, K Kirschhofer, PK Legan, DC Hughes… - Nature …, 1998 - nature.com
The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia
bundles of specialized sensory hair cells. Sound induces movement of these hair cells …
bundles of specialized sensory hair cells. Sound induces movement of these hair cells …
Svp1p defines a family of phosphatidylinositol 3, 5‐bisphosphate effectors
Phosphatidylinositol 3,5‐bisphosphate (PtdIns(3,5)P 2 ), made by Fab1p, is essential for
vesicle recycling from vacuole/lysosomal compartments and for protein sorting into …
vesicle recycling from vacuole/lysosomal compartments and for protein sorting into …
Adaptations to endurance and strength training
The capacity for human exercise performance can be enhanced with prolonged exercise
training, whether it is endurance- or strength-based. The ability to adapt through exercise …
training, whether it is endurance- or strength-based. The ability to adapt through exercise …
Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake
Advancing age is associated with a progressive loss of skeletal muscle (SkM) mass and
function. Given the worldwide aging demographics, this is a major contributor to morbidity, …
function. Given the worldwide aging demographics, this is a major contributor to morbidity, …
[PDF][PDF] Vac14 controls PtdIns (3, 5) P2 synthesis and Fab1-dependent protein trafficking to the multivesicular body
Background: The PtdIns3P 5-kinase Fab1 makes PtdIns(3,5)P 2 , a phosphoinositide essential
for retrograde trafficking between the vacuole/lysosome and the late endosome and also …
for retrograde trafficking between the vacuole/lysosome and the late endosome and also …
Effects of aging, exercise, and disease on force transfer in skeletal muscle
DC Hughes, MA Wallace… - American Journal of …, 2015 - journals.physiology.org
The loss of muscle strength and increased injury rate in aging skeletal muscle has previously
been attributed to loss of muscle protein (cross-sectional area) and/or decreased neural …
been attributed to loss of muscle protein (cross-sectional area) and/or decreased neural …
The ketogenic diet preserves skeletal muscle with aging in mice
The causes of the decline in skeletal muscle mass and function with age, known as sarcopenia,
are poorly understood. Nutrition (calorie restriction) interventions impact many cellular …
are poorly understood. Nutrition (calorie restriction) interventions impact many cellular …
Identification of the true human orthologue of the mouse Zp1 gene: evidence for greater complexity in the mammalian zona pellucida?
DC Hughes, CLR Barratt - Biochimica Et Biophysica Acta (BBA)-Gene …, 1999 - Elsevier
The mammalian zona pellucida is a mixture of glycoproteins, believed to be encoded by
three distinct genes, ZP1/ZPB, ZP2/ZPA, and ZP3/ZPC. We have now determined that the true …
three distinct genes, ZP1/ZPB, ZP2/ZPA, and ZP3/ZPC. We have now determined that the true …
Genetics of muscle strength and power: polygenic profile similarity limits skeletal muscle performance
DC Hughes, SH Day, II Ahmetov… - Journal of sports …, 2011 - Taylor & Francis
Environmental and genetic factors influence muscle function, resulting in large variations in
phenotype between individuals. Multiple genetic variants (polygenic in nature) are thought to …
phenotype between individuals. Multiple genetic variants (polygenic in nature) are thought to …
Skeletal muscle cells possess a 'memory'of acute early life TNF-α exposure: role of epigenetic adaptation
Sufficient quantity and quality of skeletal muscle is required to maintain lifespan and
healthspan into older age. The concept of skeletal muscle programming/memory has been …
healthspan into older age. The concept of skeletal muscle programming/memory has been …