Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are key regulators of the apoptotic
process. This family comprises proapoptotic and prosurvival proteins, and shifting the balance …

Apoptosis can be triggered by members of the Bcl-2 protein family, such as Bim, that share
only the BH3 domain with this family. Gene targeting in mice revealed important physiological …

Apoptosis is initiated when Bcl-2 and its prosurvival relatives are engaged by proapoptotic
BH3-only proteins via interaction of its BH3 domain with a groove on the Bcl-2-like proteins. …

Commitment of cells to apoptosis is governed largely by the interaction between members
of the Bcl-2 protein family. Its three subfamilies have distinct roles: The BH3-only proteins …

Programmed cell death (apoptosis) serves to remove excess, damaged, or infected cells
throughout the lifespan of an organism. This process is critical for development of all metazoans…

Certain members of the Bcl‐2 family inhibit apoptosis while others facilitate this physiological
process of cell death. An expression screen for proteins that bind to Bcl‐2 yielded a small …

Bcl-2 family members that have only a single Bcl-2 homology domain, BH3, are potent
inducers of apoptosis, and some appear to play a critical role in developmentally programmed …

A central issue in the regulation of apoptosis by the Bcl-2 family is whether its BH3-only
members initiate apoptosis by directly binding to the essential cell-death mediators Bax and Bak, …

Since apoptosis is impaired in malignant cells overexpressing prosurvival Bcl-2 proteins, drugs
mimicking their natural antagonists, BH3-only proteins, might overcome chemoresistance…

Platelets are anuclear cytoplasmic fragments essential for blood clotting and wound healing.
Despite much speculation, the factors determining their life span in the circulation are …