Background Drusen are extracellular lesions characteristic of aging and age-related maculopathy,
a major retinal disease of the elderly. We determined the relative proportions of lipids …

The metabolic events associated with maintaining redox homeostasis in Mycobacterium
tuberculosis (Mtb) during infection are poorly understood. Here, we discovered a novel redox …

Aims Acute coronary syndromes (ACSs) are driven by inflammation within coronary plaque.
Interleukin-1 (IL-1) has an established role in atherogenesis and the vessel-response to …

Background—Cytokine gene variations are contributory factors in inflammatory pathology.
Allele frequencies of interleukin (IL)-1 cluster genes [IL-1A(-889), IL-1B(-511), IL-1B(+3953), IL…

The mechanisms that allow Mycobacterium tuberculosis (Mtb) to persist in human tissue for
decades and to then abruptly cause disease are not clearly understood. Regulatory …

Constitutional SMARCB1 mutations at 22q11.23 have been found in ∼50% of familial and <10%
of sporadic schwannomatosis cases 1 . We sequenced highly conserved regions along …

The proinflammatory cytokine interleukin (IL)-1 is expressed mainly within the endothelium of
atherosclerotic plaques and may be linked with inflammatory mechanisms of atherogenesis…

Rationale: DNA methylation is an important epigenetic mechanism, which often occurs in
response to environmental stimuli and is crucial in regulating gene expression. It is likely that …

Background—Restenosis after percutaneous coronary intervention remains a serious
clinical problem. Progress in local gene therapy to prevent restenosis has been hindered by …

Venezuelan equine encephalitis virus (VEEV) is a representative member of the New World
alphaviruses. It is transmitted by mosquito vectors and causes highly debilitating disease in …