[PDF][PDF] Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
…, I Nicol Ferrier, A Anjorin, A Farmer, D Curtis… - Nature …, 2008 - nature.com
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases
and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10 −…
and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10 −…
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide
association study of 41,917 bipolar disorder cases and 371,549 controls of European …
association study of 41,917 bipolar disorder cases and 371,549 controls of European …
[PDF][PDF] Modeling linkage disequilibrium increases accuracy of polygenic risk scores
Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …
become more accurate as training sample sizes increase. The standard approach for …
Rare coding variants in ten genes confer substantial risk for schizophrenia
Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
The Reuven Ramaty high-energy solar spectroscopic imager (RHESSI)
RHESSI is the sixth in the NASA line of Small Explorer (SMEX) missions and the first
managed in the Principal Investigator mode, where the PI is responsible for all aspects of the …
managed in the Principal Investigator mode, where the PI is responsible for all aspects of the …
Genome-wide association study identifies 30 loci associated with bipolar disorder
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …
Amino acid transmitters in the mammalian central nervous system
DR Curtis, GAR Johnston - … Physiologie Reviews of Physiology, Volume 69, 1974 - Springer
Two decades ago insufficient information was available for amino acids to be seriously
considered as synaptic transmitters in the mammalian central nervous system (CNS). Even as …
considered as synaptic transmitters in the mammalian central nervous system (CNS). Even as …
Barrett's esophagus: a prevalent, occult complication of gastroesophageal reflux disease
C Winters Jr, TJ Spurling, SJ Chobanian, DJ Curtis… - Gastroenterology, 1987 - Elsevier
A prospective study of patients with symptoms of gastroesophageal reflux was undertaken
to determine the prevalence of Barrett's esophagus and reevaluate the diagnostic approach …
to determine the prevalence of Barrett's esophagus and reevaluate the diagnostic approach …
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has …
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has …