In situ hybridization is used to reveal the location of specific nucleic acids sequences on
chromosomes or in tissues. Visualization of the location of genes on chromosomes or of specific …

… Members of the Eph receptor Klaus Strebhardt,§ Hisamaru Hirai, family display dynamic
and spatially restricted expresDavid G. Wilkinson,‡ Tony Pawson,† Samuel Davis,* sion …

FORMATION of mesoderm is a crucial event in vertebrate development, establishing many
of the important features of the body 1–4 . Recent studies have implicated molecules that are …

Slug, a vertebrate gene encoding a zinc finger protein of the Snail family, is expressed in
the neural crest and in mesodermal cells emigrating from the primitive streak. Early chick …

The control of cell movement during development is essential for forming and stabilizing the
spatial organization of tissues and cell types. During initial steps of tissue patterning, distinct …

Detection of messenger RNA by in Situ hybridization to tissue sections and whole mounts |
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Eph proteins are receptors with tyrosine-kinase activity which, with their ephrin ligands,
mediate contact-dependent cell interactions 1 that are implicated in the repulsion mechanisms …

Eph receptor tyrosine kinases and ephrins have key roles in regulation of the migration and
adhesion of cells required to form and stabilize patterns of cell organization during …

The restriction of intermingling between specific cell populations is crucial for the maintenance
of organized patterns during development. A striking example is the restriction of cell …

Publisher Summary This chapter discusses the in situ hybridization analysis of chick
embryos in whole mount and tissue sections. The in situ analysis of the temporal and spatial …