Recombinant adeno-associated viruses (AAVs) are commonly used gene delivery vehicles
for neuroscience research. They have two engineerable features: the capsid (outer protein …

Advances in adeno-associated virus (AAV) engineering have provided exciting new tools for
research and potential solutions for gene therapy. However, the lung has not received the …

Genetic intervention is increasingly being explored as a therapeutic option for debilitating
disorders of the central nervous system. The safety and efficacy of gene therapies rely upon …

The blood-brain barrier (BBB) presents a major challenge for delivering large molecules to
study and treat the central nervous system. This is due in part to the scarcity of targets known …

Delivering genes to and across the brain vasculature efficiently and specifically across
species remains a critical challenge for addressing neurological diseases. We have evolved …

Genetic intervention is increasingly explored as a therapeutic option for debilitating disorders
of the central nervous system. The safety and efficacy of gene therapies relies upon …

The blood-brain barrier (BBB) presents a major challenge to delivering large molecules to
study and treat the central nervous system (CNS). This is due in part to the scarcity of effective …

Adeno-associated viruses (AAVs) remain promising vectors for gene therapy due to stable
expression in vivo and a strong clinical safety record. Unfortunately, naturally occurring AAV …

Adeno-associated virus research is critical for the advancement of gene therapy and treatment
of myriad debilitating genetic disorders. Targeted delivery of genetic components to a …

… In a new study, a research team led by first authors David Goertsen, Nicholas Flytzanis and
Nick Goeden, from the Gradinaru lab at the California Institute of Biology, engineered AAV …